<p>Hiroyuki Nakazawa, Murakami Takayasu, Hidetoshi Hoshikawa, Kenta Sawazaki.</p><p>Faculty of Health Promotional Science,Tokoha University</p><p><br/></p><p style="text-align: justify;">Abstract</p><p style="text-align: justify;"><strong>Introduction</strong>: Life under stress conditions is known to easily induce various diseases such as psychosomatic disorder.Although it has been reported that tactile stimulation is effective against stress symptoms/diseases, details of mechanism are unknown.This study observes the effects of the central nervous system on the non-invasive skin stimulation.</p><p style="text-align: justify;"><strong>Methods: </strong>Experiments were performed on model rats with chronic stress (Specific Alternation of Rhythm in Temperature:SART stress model). Rats were classified into two groups (n=10) of the noninvasive skin stimulationby microcones group (stimulation site corresponding to ST-36, A) and the control group (C).Evaluation was a change in dopamine dynamics in the brain.</p><p style="text-align: justify;"><strong>Result/Discussion:</strong> In group C, there was no significant difference in dopamine release between before and after intervention by non-invasive skin stimulation.In groupA, the release of dopamine increased due to stimulation, and a significant difference was observed after 20 minutes from that before the intervention.It was suggested that non-invasive skin stimulation to the site corresponding to ST-36 may have an effect on the dopamine nervous system in the brain.</p><p><br/></p><p>Key word: tactile stimulation,non-invasive skin stimulation, microcone, dopamine, acupuncture point,&nbsp;</p><p><br/></p>