<p style="text-align: center;">Wang Gelu^1,3, Dong Pei ^1,3, Wang Shenjun ^1,2</p><p style="text-align: center;">(1 Experimental Acupuncture and Moxibustion Research Center, Tianjin University of Traditional Chinese Medicine; 2 Acupuncture and Massage College of Tianjin University of Traditional Chinese Medicine; and 3 Graduate School of Tianjin University of Traditional Chinese Medicine)</p><p style="text-align: justify;"><strong>Abstract</strong>: Chinese medicine treatment of depression has a good clinical efficacy, but the mechanism of action has not been elucidated. With the rapid development of science, there are more and more animal experiments on&nbsp; Chinese&nbsp; medicine&nbsp; for&nbsp; the&nbsp; treatment&nbsp; of&nbsp; depression.&nbsp; However,&nbsp; the&nbsp; establishment&nbsp; of&nbsp; animal&nbsp; models&nbsp; is diversified and there is a lack of uniform standards. Western animal model is the earliest used&nbsp; to study the mechanism of disease, Chinese medicine in the process of internationalization trying to learn from Western animal&nbsp; model&nbsp; to&nbsp; study&nbsp; the&nbsp; pathology&nbsp; of&nbsp; Chinese&nbsp; medicine,&nbsp; but&nbsp; the&nbsp; basic&nbsp; theoretical&nbsp; system&nbsp; of&nbsp; Western medicine are different. Therefore, the establishment of animal model of depression is consistent with Chinese medicine theory? This is a problem that we pay close attention to.</p><p style="text-align: justify;"><strong>Key words</strong>: Depression, Chinese medicine, animal model</p><p><br/></p>