<p style="text-align: center;">Liu Yuli, Zhang lide, Liu Haitao, Song Sitong, Wang xu, Li ning, Yang chang, Yu song</p><p style="text-align: center;">（1 Liaoning University of Traditional Chinese Medicine, Shenyang 110847；2&nbsp; &nbsp;The General Hospital of Chinese People&#39;s Armed Police Force&nbsp; &nbsp;Beijing10039；3 Heilongjiang Provincial Hospital of traditional Chinese Medicine Haerbin 150036）</p><p style="text-align: justify;"><strong>Objective</strong>：To investigate the effect of manual single point &quot;Feishu&quot; acupoint on interleukin -1 beta and 6 in lung tissue of bronchial asthma. Methods：40 Wistar rats were randomly divided into the normal control group, the model group, the &quot;Feishu&quot; acupoint group and the non-channel-non-acupoint group, 10 rats in each group. Ovalbumin (OVA) to establish the rat model of asthma induced by sensitized, Hematoxylin eosin (He)&nbsp; staining&nbsp; was&nbsp; used&nbsp; to&nbsp; observe&nbsp; the&nbsp; pathological&nbsp; changes&nbsp; of&nbsp; lung&nbsp; tissue&nbsp; in&nbsp; rats,&nbsp; Enzyme&nbsp; linked immunosorbent assay (ELISA) was used to detect the levels of interleukin -1 beta (IL-1 beta) and interleukin -6 (IL-6) in the lung tissue of rats.&nbsp; Results：Acupuncture &quot;Feishu&quot; point can alleviate the inflammatory pathological&nbsp; changes&nbsp; of&nbsp; bronchial&nbsp; asthma&nbsp; model,&nbsp; reduce&nbsp; airway&nbsp; thickening&nbsp; and&nbsp; inflammatory&nbsp; cell aggregation, and have obvious difference compared with&nbsp; non-channel-non-acupoint&nbsp; acupoints. The resultsof ELISA showed that acupuncture &quot;Feishu&quot; point could lower the elevated IL-1 and beta levels in bronchial asthma, the difference was statistically significant (P&nbsp; =0.009), and it was different from that of the&nbsp; nonchannel-non-acupoint&nbsp; group.&nbsp; However,&nbsp; manual&nbsp; acupuncture&nbsp; of&nbsp; single&nbsp; point&nbsp; &quot;Feishu&nbsp; &quot;&nbsp; acupoint&nbsp; can&nbsp; not significantly&nbsp; reduce&nbsp; the&nbsp; elevated&nbsp; IL-6&nbsp; content&nbsp; in&nbsp; bronchial&nbsp; asthma&nbsp; (P&nbsp; =0.131).&nbsp; <strong>Conclusion</strong>： Manual acupuncture of single acupoint can regulate IL-1 beta in bronchial asthma and play a benign regulatory role, but it does not affect the content of IL-6.&nbsp; &nbsp;</p><p style="text-align: justify;"><strong>Keywords</strong>：acupuncture, “Feishu”, bronchial asthma,&nbsp; IL-1 beta,&nbsp; IL-6</p><p><br/></p>