<p style="text-align: center;">Hiroyuki Nakazawa, Murakami Takayasu, Hidetoshi Hoshikawa, Kenta Sawazaki.</p><p style="text-align: center;">(Faculty of Health Promotional Science,Tokoha University)</p><p style="text-align: justify;"><strong>Abstract:</strong>&nbsp;<strong> Introduction</strong>: Life under stress conditions is known to easily induce various diseases such as psychosomatic disorder.Although it has been reported that tactile stimulation is effective against&nbsp; stress&nbsp; symptoms/diseases,&nbsp; details&nbsp; of&nbsp; mechanism&nbsp; are&nbsp; unknown.This&nbsp; study&nbsp; observes&nbsp; the effects of the central nervous system on the non-invasive skin stimulation. Methods: Experiments were&nbsp; performed&nbsp; on&nbsp; model&nbsp; rats&nbsp; with&nbsp; chronic&nbsp; stress&nbsp; (Specific&nbsp; Alternation&nbsp; of&nbsp; Rhythm&nbsp; in Temperature:SART stress model). Rats were classified into two groups (n=10) of the noninvasive skin stimulationby microcones group (stimulation site corresponding to ST -36, A) and the control group&nbsp; (C).Evaluation&nbsp; was&nbsp; a&nbsp; change&nbsp; in&nbsp; dopamine&nbsp; dynamics&nbsp; in&nbsp; the&nbsp; brain.&nbsp; Result/Discussion:In group&nbsp; C,&nbsp; there&nbsp; was&nbsp; no&nbsp; significant&nbsp; difference&nbsp; in&nbsp; dopamine&nbsp; release&nbsp; between&nbsp; before&nbsp; and&nbsp; after intervention by non-invasive skin&nbsp; stimulation.In groupA, the release of dopamine increased due to stimulation,&nbsp; and&nbsp; a&nbsp; significant&nbsp; difference&nbsp; was&nbsp; observed&nbsp; after&nbsp; 20&nbsp; minutes&nbsp; from&nbsp; that&nbsp; before&nbsp; the intervention.It was suggested that non-invasive skin stimulation to the site corresponding to ST -36 may have an effect on the dopamine nervous system in the brain.</p><p><strong>Key words</strong>: tactile stimulation,non-invasive skin stimulation, microcone, dopamine, acupuncture point</p><p><br/></p>