<p style="text-align: center;">CHEN Xianghong, CHEN Bo , CHEN Zelin ,GUO Yi, LI Mengdan, LONG Qin</p><p style="text-align: center;">（1 College of Acupuncture and Massage，Tianjin University of Traditional Chinese Medicine，Tianjin，300193，China；2 Research Center of Experimental Acupuncture Science，Tianjin University of Traditional Chinese Medicine，Tianjin，300193，China）</p><p style="text-align: justify;"><strong>ABSTRACT</strong>： Summarizing the relevant literature on the&nbsp; mechanism of blistering cupping therapy in recent years, to further explore the mechanism of clinical investigation on blistering cupping therapy. This&nbsp; paper&nbsp; discusses&nbsp; the&nbsp; traditional&nbsp; view,&nbsp; modern&nbsp; research&nbsp; and&nbsp; blister&nbsp; research of&nbsp; the mechanism of cupping therapy. The blistering cupping therapy as a new type of cupping therapy was&nbsp; accepted&nbsp; by&nbsp; more&nbsp; physicians.&nbsp; However,&nbsp; the&nbsp; study&nbsp; of&nbsp; the&nbsp; clinical&nbsp; application&nbsp; of&nbsp; blistering cupping therapy is very important, and the mechanism study is relatively backward. There&nbsp; is no systematic way of explaining its mechanism. Therefore, So the author thinks that the blistering cupping is on the basis of the cupping, through the way of blistering , Activate the neuroendocrine&nbsp; -&nbsp; immune&nbsp; network,&nbsp; and&nbsp; activate&nbsp; the&nbsp; immune&nbsp; system,&nbsp; The&nbsp; curative&nbsp; effect&nbsp; can&nbsp; be improved&nbsp; by&nbsp; removing&nbsp; the&nbsp; disease&nbsp; .Comprehensive&nbsp; exploration&nbsp; blistering&nbsp; cupping&nbsp; therapy mechanism further, It is not only important for the promotion of blistering cupping therapy, but also it is helpful to guide clinical treatment and improve clinical application.</p><p><strong>KEY WORDS</strong>: cupping；blistering cupping；mechanism&nbsp;</p><p><br/></p>