<p style="text-align: center;">Liu Yamin, Sun Zhongren</p><p style="text-align: center;">(Heilongjiang University of Traditional Chinese Medicine, Harbin150040, Heilongjiang, China)</p><p style="text-align: justify;"><strong>Abstract</strong>:&nbsp; With&nbsp; the&nbsp; increasing&nbsp; pressure&nbsp; of&nbsp; modern&nbsp; life,&nbsp; young&nbsp; and&nbsp; middle-aged&nbsp; women,&nbsp; both suffering&nbsp; from&nbsp; thyroid&nbsp; nodules,&nbsp; breast&nbsp; hyperplasia,&nbsp; Leiomyoma,&nbsp; one&nbsp; of&nbsp; the&nbsp; two&nbsp; or&nbsp; three diseases&nbsp; ,besides&nbsp; ,the&nbsp; number&nbsp; of&nbsp; patients&nbsp; is&nbsp; constantly&nbsp; increasing.&nbsp; Hypothalamo&nbsp; -&nbsp; pituitary&nbsp; -gonadal axis (HPGA) changes have a correlation with the incidence of thyroid nodules, breast hyperplasia,&nbsp; Leiomyoma&nbsp; .In&nbsp; recent&nbsp; years,&nbsp; many&nbsp; scholars&nbsp; study&nbsp; the&nbsp; network&nbsp; regulation&nbsp; of reproductive function by acupuncture from the overall gene-cell-gene level.Acupuncture treatment of&nbsp; reproductive&nbsp; and&nbsp; endocrine&nbsp; diseases&nbsp; have&nbsp; achieved&nbsp; a&nbsp; certain&nbsp; effect.Acupuncture&nbsp; and moxibustion&nbsp; on&nbsp; the&nbsp; gonadal&nbsp; axis&nbsp; from&nbsp; the&nbsp; center&nbsp; to&nbsp; the&nbsp; gonadal&nbsp; regulation&nbsp; mechanism&nbsp; of experimental&nbsp; research&nbsp; has&nbsp; made&nbsp; many&nbsp; new&nbsp; advance.Acupuncture&nbsp; on&nbsp; the&nbsp; (HPGA)&nbsp; &nbsp;has&nbsp; a significant regulatory role.Its role may be related to acupuncture regulating hypothalamic-pituitary β-endorphin level and promoting the expression of c-fos and other third messengers.However, the existing studies are scattered and repetitive, and there is a lack of large-scale and serialized research on&nbsp; comprehensive&nbsp; multidisciplinary&nbsp; cooperation.There&nbsp; are&nbsp; many&nbsp; mechanisms&nbsp; are&nbsp; not&nbsp; clear, pending&nbsp; further&nbsp; study&nbsp; and&nbsp; research.This&nbsp; article&nbsp; discusses&nbsp; the&nbsp; relationship&nbsp; between&nbsp; the hypothalamic pituitary gland axis and thyroid nodules, breast hyperplasia and uterine fibroids from the perspective of holistic perspective.From a macro point of view, the occurrence of such diseases may be the body&#39;s internal environment suitable for their growth, proliferation,This change in the internal environment, of course, appears to gasification disorders，If you can adjust its abnormal gasification,&nbsp; so&nbsp; that&nbsp; the&nbsp; body&#39;s&nbsp; gasification&nbsp; activity&nbsp; back&nbsp; to&nbsp; the&nbsp; original&nbsp; state&nbsp; of&nbsp; order,&nbsp; Then eliminate&nbsp; the&nbsp; nodules&nbsp; within&nbsp; the&nbsp; environment 。 The&nbsp; overall&nbsp; regulation&nbsp; is&nbsp; the&nbsp; advantage&nbsp; of acupuncture.Acupuncture can adjust the endocrine system function in a bidirectional, benign and whole way according to the pathological state of human body and other related factors to achieve the&nbsp; stability&nbsp; and&nbsp; balance&nbsp; of&nbsp; the&nbsp; body&nbsp; and&nbsp; maintaining&nbsp; the&nbsp; balance&nbsp; of&nbsp; internal&nbsp; and&nbsp; external environment. The overall regulation is the advantage of acupuncture.Acupuncture treatment can promote blood circulation, Endometriosis, improve local blood circulation, strengthen the local tissue metabolism, in order to facilitate atrophy and absorption of nodules. Acupuncture can play a role in the treatment of endocrine system diseases and gynecological diseases.</p><p style="text-align: justify;"><strong>Key words</strong>:&nbsp; Acupuncture, Hypothalamo-pituitary-gonadal axis (HPGA), Thyroid nodules, breast hyperplasia,</p><p style="text-align: justify;">Leiomyoma</p><p><br/></p>