<p style="text-align: center;">PAN Youcan,XU Nenggui,YI Wei,SHI Junheng,GUO Lili</p><p style="text-align: center;">（Southern China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine，Guangzhou&nbsp; &nbsp;510000，China）</p><p style="text-align: justify;"><strong>Abstract</strong>: <strong>Objective</strong>: To observe the effect of Electroacupuncture on the behavior of learning and memory in diabetic mice, and to investigate the Protective effects of Electroacupuncture on the neurons in high glucose. Methods: A total of 48 8-week-old male C 57 BL/6 mice were randomly divided into sodium chloride group, sodium chloride + electroacupuncture group, diabetic model group (STZ), diabetic model Plus Electroacupuncture group, 12 rats in each group. Diabetes model was induced by 150&nbsp; mg/kg streptozotocin (STZ) injection. Electroacupuncture at &quot;Baihui&quot; (GV&nbsp;</p><p style="text-align: justify;">20) &quot;Shenshu&quot;(BL 23)&nbsp; &nbsp;&quot;Zusanli&quot;（ST 36）,&nbsp; &nbsp;voltage 2～4 V, frequency 2 Hz, once every other day, 20 min each time, 28 consecutive D. After 28 D, the mice were subjected to water maze and Passive avoidance test, and the density of dendrites of neurons in mice was observed by Golgi staining. Results: The diabetic model group compared with the sodium chloride group increased blood glucose (P&lt;0.05) and insulin resistance (P&lt;0.05), glucose (P&lt;0.05) and insulin resistance (P&lt;0.05),diabetic&nbsp; model&nbsp; +&nbsp; EA&nbsp; group&nbsp; compared&nbsp; with&nbsp; the&nbsp; diabetic&nbsp; model&nbsp; group&nbsp; reduced&nbsp; blood glucose&nbsp; (P&lt;0.05),&nbsp; elevated&nbsp; ins&nbsp; ulin&nbsp; levels&nbsp; (P&lt;0.05);&nbsp; water&nbsp; maze&nbsp; test,28,&nbsp; 29&nbsp; D&nbsp; navigation experiment Part, the diabetic model group compared with the sodium chloride group escape the latency was increased (P&lt;0.05), diabetic model + EA group compared with the diabetic model group&nbsp; (P&lt;0.05),&nbsp; the&nbsp; escape&nbsp; latency&nbsp; decreased&nbsp; 30,&nbsp; 31&nbsp; D&nbsp; of&nbsp; space&nbsp; exploration&nbsp; experiment,&nbsp; the diabetic model group compared with the sodium chloride group escape&nbsp; latency increased (P&lt;0.05), diabetes mellitus model + EA group compared with the diabetic model group (P&lt;0.05), the escape latency decreased 32 D on space exploration of experimental diabetic model group compared with the&nbsp; sodium&nbsp; chloride&nbsp; group&nbsp; increased&nbsp; escape&nbsp; latency&nbsp; (P&lt;0.05),&nbsp; diabetic&nbsp; model&nbsp; +&nbsp; EA&nbsp; group compared&nbsp; with&nbsp; the&nbsp; diabetic&nbsp; model&nbsp; group&nbsp; to&nbsp; avoid&nbsp; Potential&nbsp; Ummer&nbsp; reduced&nbsp; (P&lt;0.05),&nbsp; in&nbsp; the Passive avoidance test, during the 14 and 28 d memory test, the diabetic model group compared with the sodium chloride group was reduced (P&lt;0.05), diabetic model + EA group compared with the diabetic model group increased latency (P&lt;0.05); diabetes model group compared with the sodium chloride group reduction of dendritic spine density (P&lt;0.05), model + EA group compared</p><p style="text-align: justify;">with&nbsp; the&nbsp; diabetic&nbsp; model&nbsp; group&nbsp; increased&nbsp; dendritic&nbsp; density&nbsp; (P&lt;0.05).<strong>Conclusion&nbsp;</strong>Electroacupuncture&nbsp; can&nbsp; improve&nbsp; diabetic&nbsp; cognitive&nbsp; dysfunction,&nbsp; which&nbsp; may&nbsp; be&nbsp; related&nbsp; to regulating the density of neuronal dendrites.</p><p style="text-align: justify;"><strong>Key&nbsp; words</strong>: Acupuncture&nbsp; and&nbsp; Moxibustion,&nbsp; Learning&nbsp; and&nbsp; memory ,&nbsp; High&nbsp; glucose,&nbsp; Dendrites, Dendrites spain&nbsp;</p><p><br/></p>