<p style="text-align: center;">YI Wei,PAN Youcan,XUN Nenggui, SHING Junhen,ZHENG Xiaoyan</p><p style="text-align: justify;">（Southern China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine，Guangzhou 510006，China）</p><p style="text-align: justify;"><strong>Abstract</strong>：<strong>Objective</strong>：&nbsp; To observe the effect of electroacupuncture on learning and memory behavior&nbsp; of&nbsp; hypoxic-ischemic&nbsp; young&nbsp; rats,&nbsp; and&nbsp; to&nbsp; explore&nbsp; the&nbsp; protective&nbsp; effect&nbsp; of electroacupuncture on neurons in hypoxic-ischemic rats. Methods：&nbsp; A total of 50 SD rats aged 7 days were randomly divided into the sham operation group (Sham), the model group (HIE), and the electroacupuncture group (HIE+EA). The HIE model was established by ligation of the le ft&nbsp;</p><p style="text-align: justify;">common carotid artery combined with hypoxia. Electroacupuncture at &quot;Baihui&quot; （GV 20） “Dazhui” (GV 14), once every other day, 20 min each time, 28 consecutive D. At the beginning of twentyninth D, the density of dendritic spines of young rats was observed by Golgi staining. <strong>Results</strong>：Rotarod and elevated maze test, no differences between the three groups (P&gt;0.05); water maze test,&nbsp; the&nbsp; model&nbsp; group&nbsp; compared&nbsp; with&nbsp; the&nbsp; sham&nbsp; operation&nbsp; group (P&lt;0.05),&nbsp; the&nbsp; escape&nbsp; latency increased escape distance increased (P&lt;0.05), the platform quadrant time reduced (P&lt;0.05), cross platform (P&lt;0.05), reduce the number of EA group escape reduce the latency (P&lt;0.05), reduce the escape&nbsp; distance&nbsp; in platform&nbsp; quadrant time&nbsp; increased (P&lt;0.05),&nbsp; the&nbsp; &nbsp;increase&nbsp; in the number&nbsp; of crossing&nbsp; platform&nbsp; (P&lt;0.05). Compared with the sham operation group, the Density&nbsp; of dendritic spines decreased (p&lt;0.05) in the model group, and the density of dendritic spines in the EA group was higher than that in the model group (P&lt;0.05). Conclusion&nbsp; &nbsp;Electroacupuncture can improve the learning and memory ability of young rats induced by hypoxia and ischemia, and the effect may be related to regulating the density of dendritic dendritic spines.</p><p style="text-align: justify;"><strong>Key words</strong> :&nbsp; Acupuncture and Moxibustion, Learning and memory, Hypoxia-ischemia, Dendritic spines</p><p><br/></p>