<p style="text-align: center;">ZHU Yi, DONG Hongsheng, DONG Guirong</p><p style="text-align: justify;">(Department ofAcupuncture,Yueyang Hospital of Integrated Traditional Chinese Western Medicine, Shanghai University of Traditional Chinese Medicine，Shanghai, 200437)</p><p style="text-align: justify;"><strong>Abstract</strong>:&nbsp; TLRs&nbsp; is&nbsp; basic&nbsp; member&nbsp; of&nbsp; the&nbsp; innate&nbsp; immune&nbsp; which&nbsp; belong&nbsp; to&nbsp; a&nbsp; family&nbsp; of&nbsp; pattern recognition receptors ( PRRs). Growing evidence has demonstrated that TLRs play a critical role in myocardial ischemia/reperfusion injury.&nbsp; Specifically, the research of TLR2 and TLR4 is the most widespread. The cardiomyocyte can release some substance which can bind to TLR after ischemia．&nbsp; Through several signal transduction pathways，nuclear factor κB can be activated，which&nbsp; lead&nbsp; to&nbsp; the&nbsp; production&nbsp; of&nbsp; proinflammation&nbsp; factors ．Coincidently，inflammation&nbsp; postmyocardial infarction is a key determinant of the left ventricular remodeling．In this review，we will focus on the recent progresses of TLR2 and TLR4 in&nbsp; myocardial&nbsp; I/R&nbsp; injury．Preliminary clarify the mechanism of TLRs in myocardial I/R injury and provided new insight into the clinical treatment.</p><p style="text-align: justify;"><strong>Key word</strong><strong>s</strong>:&nbsp; Acupuncture,&nbsp; Toll-like&nbsp; receptor&nbsp; 2,&nbsp; Toll-like&nbsp; receptor&nbsp; 4,&nbsp; Signaling&nbsp; transduction, Myocardial ischemia/reperfusion injury&nbsp;</p><p><br/></p>